The Effect of Prostatic Urethral and Seminal Vesicle Morphometry on Multiparametric Prostate Magnetic Resonance Imaging on Ejaculation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 150
- 试验地点
- 1
研究概览
简要总结
The goal of this observational study is to learn whether the size and shape of the prostatic urethra and seminal vesicles - measured on multiparametric prostate MRI (mpMRI) - are related to premature ejaculation (PE) severity in men aged 18-55.
The main questions it aims to answer are:
- Do men with premature ejaculation have different prostatic urethral length and angulation compared to men without PE?
- Do men with premature ejaculation have different seminal vesicle dimensions compared to men without PE?
- Do prostatic urethra and seminal vesicle measurements on mpMRI correlate with PE severity scores (PEDT) and ejaculation latency time (IELT)?
Researchers will compare men with premature ejaculation to healthy men without ejaculatory complaints to see if specific anatomical features are associated with PE severity.
Participants will:
- Undergo a multiparametric prostate MRI that is already scheduled as part of their routine medical care
- Complete validated questionnaires about ejaculation and sexual function (PEDT, PEP, IELT, IIEF-15)
- Provide a blood sample for routine hormone level measurements
详细描述
Premature ejaculation (PE) is the most common male sexual dysfunction, affecting approximately 20-30% of men worldwide. Despite its high prevalence, its pathophysiology remains incompletely understood. While neurobiological and psychological factors have been extensively studied, the potential role of anatomical variations in the lower urinary tract
- specifically the prostatic urethra and seminal vesicles - has received limited attention in the literature.
The seminal vesicles play a key role in ejaculation by contributing approximately 70% of seminal fluid volume. Previous ultrasound-based studies have suggested a possible relationship between seminal vesicle size and PE severity. However, no study to date has investigated prostatic urethral and seminal vesicle morphometry using the superior spatial resolution of multiparametric prostate MRI (mpMRI) in relation to PE.
STUDY DESIGN:
Single-center, prospective, observational cohort study conducted at Başakşehir Çam ve Sakura City Hospital Urology Clinic, Istanbul, Turkey.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •- Male aged 18 to 55 years
- •In a stable, heterosexual, monogamous relationship with the same female partner for at least 6 months
- •Normal erectile function defined as IIEF-15 erectile function domain score ≥26
- •Scheduled for clinically indicated multiparametric prostate MRI due to elevated PSA or hematospermia
- •Not using any medication that may affect sexual function or psychological status (e.g., SSRIs, PDE5 inhibitors)
排除标准
- •Any major psychiatric or somatic disorder
- •Hormonal disorders such as hypothyroidism or hyperthyroidism
- •Erectile dysfunction (IIEF-15 erectile function domain score <26)
- •Age below 18 or above 55 years
研究者
SEZGIN
MD VEYSEL SEZGİN
Başakşehir Çam & Sakura City Hospital