An Acute Intervention Study Investigating the Effect of Red Raspberry Consumption on Post-prandial Oxidative Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- change in antioxidant capacity from baseline (-0.25 h)
研究概览
简要总结
Eight healthy adult subjects will be given a meal of one, two or four cups red raspberries, or two slices white bread with or without 200 mg vitamin C, after an overnight fast and consumption of a low polyphenol diet for two days. Blood samples will be taken at various time points over an eight hour period to measure oxidative stress and antioxidant levels in the blood. Each subject will attend 5 study visits with one week intervals and be given each meal in a random order. It is hypothesized that raspberry consumption at higher doses will greater protect against meal-induced oxidative stress compared to bread controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adults
排除标准
- •blood pressure greater than 120/80 mm Hg
- •body mass index greater than 24.9 kg/m^2
- •history of any chronic disease
- •currently taking medications
- •allergy to fruit
研究组 & 干预措施
one cup red raspberries
treatment meal consists of one cup red raspberries
干预措施: red raspberries (Dietary Supplement)
two cups red raspberries
treatment meal consists of two cups red raspberries
干预措施: red raspberries (Dietary Supplement)
four cups red raspberries
treatment meal consists of four cups red raspberries
干预措施: red raspberries (Dietary Supplement)
bread
treatment meal consists of two slices white bread
干预措施: bread controls (Dietary Supplement)
vitamin C
treatment meal consists of two slices white bread and 200 mg vitamin C in the form of supplemental ascorbic acid
干预措施: bread controls (Dietary Supplement)
结局指标
主要结局
change in antioxidant capacity from baseline (-0.25 h)
时间窗: -0.25, 0.25, 0.5, 1, 2, 4 hours post-intake
plasma antioxidant capacity measured using the 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation assay and expressed in Trolox Equivalents (TE)
次要结局
- change in lipid peroxidation from baseline (-0.25 h)(-0.25, 0.25, 0.5, 1, 2, 4 hours post-intake)
- change in thiols compared to baseline (-0.25 h)(-025, 0.25, 0.5, 1, 2, 4 hours post-intake)