Women's Health Initiative Memory Study of Younger Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,362
- 试验地点
- 1
- 主要终点
- All-cause dementia and Mild Cognitive Impairment
研究概览
简要总结
WHIMS-Y provides valuable information on the long-term effects on risk of cognitive impairment of hormone therapy in a subset of WHI participants in the WHI Hormone Trials. Following cessation of study-prescribed HT cognitive function and impairment were assessed.
详细描述
The Women's Health Initiative Memory Study of Younger Women (WHIMS-Y) is proposed to assess the long-term impact of random assignment to postmenopausal hormone therapy (equine estrogen alone or in combination with medroxyprogesterone versus placebo) among women who were aged 50-54 at the time of randomization into the WHI hormone trials. Secondary objectives relate to the consistency of any treatment effects across unopposed or opposed therapy and whether there exists evidence of graded relationships between cognitive effects and age of administration, years from menopause, and baseline risk factors for cognitive impairment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 54 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Must be enrolled in the Women's Health Initiative Extension
排除标准
- •Not enrolled in the Women's Health Initiative Extension
结局指标
主要结局
All-cause dementia and Mild Cognitive Impairment
时间窗: Measured once a year
Participants will have a cognitive assessment administered over the telephone.
次要结局
- Global and domain specific cognitive function.(Measured once a year)