NCT07237958已完成不适用
Effects on the Olfactory Epithelium in the Nose and the Olfactory Nerve (Nervus Olfactorius) From Exposure to Diesel Exhaust
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Diesel exhaust causes cellular dysfunction of the olfactory system
研究概览
简要总结
The goal of this study is to study the effect exposure to air pollution and its effect on development of dementia.
Does the diesel exhaust change the function of the olfactory system?
Have the exposures measurable effects on the sense of smell and cognitive ability?
Forty people are exposed to diesel exhaust exhaust and filtered air. The exposures are blinded and in a randomized order. Both groups undergo biopsies of the olfactory epithelium in the nose under local anesthesia after the exposures and after performing cognitive test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-smoker
排除标准
- •Allergic rhinitis
- •Diabetes mellitus
- •Kidney or liver failure
- •Angina pectoris or previous ventricular arrhythmia
- •Systolic blood pressure >190 mmHg or <100 mmHg
- •Previous blood disease
- •Blood donation in the last three months prior to study start
- •Previous or ongoing tobacco smoking and exposure to air pollution in the workplace
- •Absence of informed consent
结局指标
主要结局
Diesel exhaust causes cellular dysfunction of the olfactory system
时间窗: 3 years.
RNA sequencing and DNA methylation will be conducted to identify biomarkers for acute exposure to diesel exhaust.
次要结局
- Cognitive test(3 years)
研究者
研究点 (2)
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