NCT00156052已完成不适用
A Randomized Trial of Hypofractionated Radiotherapy Post-Lumpectomy in Women With Node Negative Breast Cancer
Ontario Clinical Oncology Group (OCOG)22 个研究点 分布在 1 个国家目标入组 1,234 人开始时间: 1993年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,234
- 试验地点
- 22
- 主要终点
- Local breast recurrence
研究概览
简要总结
To determine if hypofractionated radiotherapy to the whole breast (4,250 cGy/16 fractions over 22 days) is equally effective to standard fractionated radiotherapy (5,000 cGy/25 fractions over 35 days) in women with node negative breast cancer who have undergone lumpectomy.
The primary outcome is local breast recurrence and secondary outcomes include morbidity and cost effectiveness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The female patient has a histological diagnosis of invasive carcinoma of the breast, and no evidence of metastatic disease.
- •Has had a lumpectomy (including segmental resection and partial mastectomy), that is, surgical excision of the tumour with a rim of normal tissue.
- •Patient has not had an axillary dissection, OR for patients who have had an axillary dissection, all nodes are negative for metastatic disease.
排除标准
- •Tumour greater than 5 cm in greatest diameter on pathological examination.
- •The presence of invasive or intraductal (noninvasive) breast cancer involving the surgical margins.
- •Clinical evidence prior to surgery of infiltration of the skin of the involved breast such as edema, ulceration, or fixation of the tumour to underlying muscle, or inflammatory breast cancer.
- •Bilateral malignancy of the breast (synchronous or metachronous).
- •More than one primary invasive tumour in the same breast.
- •Previous surgery for breast cancer.
- •Pathological status of axilla is unknown.
- •Status for adjuvant systemic therapy not determined.
- •For patients not treated with adjuvant chemotherapy: unable to commence radiation therapy within 16 weeks of last surgical procedure on the breast.
- •For patients treated with adjuvant chemotherapy: unable to commence radiation therapy within 8 weeks of the last dose of chemotherapy.
- •Serious nonmalignant disease (eg. cardiovascular, renal, etc.) which would preclude surgical or radiation treatment.
- •Currently pregnant or lactating.
- •Breast deemed too large to permit satisfactory radiation (ie. separation > 25 cm).
- •Previous concomitant malignancies of any type except squamous, or basal cell carcinomas of the skin, or carcinoma \fIin situ\fR of the cervix which have been effectively treated.
- •Geographic inaccessibility for follow-up.
- •Psychiatric or addictive disorders which preclude obtaining informed consent or adherence to the protocol.
结局指标
主要结局
Local breast recurrence
时间窗: Indefinitely
次要结局
- Morbidity(Indefinitely)
- Cost effectiveness(Indefinitely)
研究者
研究点 (22)
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