Methylphenidats Betydning for motoriskindlæring Hos Patienter Med Apopleksi
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 13
- 试验地点
- 4
- 主要终点
- Training induced changes in Short interval Intracortical Inhibition (SICI).
研究概览
简要总结
The purpose of the study is to determine whether methylphenidate facilitates so called short-term plasticity as measures with transcranial magnetic stimulation, in patients with stroke.
详细描述
Stroke patients are to be examined with transcranial magnetic stimulation (TMS) before and after a short training session. TMS will be used to demonstrate changes in cortical excitability (motor threshold) and intracortical inhibition and facilitation. The effect of methylphenidate on baseline TMS measures will be evaluated as well as the effect on training induced changes in TMS measures (by comparing baseline and posttraining measures). The patients will be trained on two separate occasions, to compare the effect of Methylphenidate to placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Less than two months after first stroke.
- •Moderate to light hand paralysis
- •Measurable MEP in the abductor pollicis brevis muscle
- •Able to read and understand the written information
- •Signed informed consent
排除标准
- •Hyperthyroidism
- •Cardiac arrythmia
- •Known heart disease or angina.
- •Metal implants
- •Pacemaker
- •Pregnancy
- •Diastolic BP>100 mmHg
- •In treatment with MAO-inhibitor, SSRIs og Ritalin
结局指标
主要结局
Training induced changes in Short interval Intracortical Inhibition (SICI).
Training induced changes in Intracortical facilitation (ICF)
次要结局
- Baseline SICI, ICF, and motor threshold compared between methylphenidate and Placebo