Pupillary Dilation Reflex (PDR) Evaluation During General Anesthesia: a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Pupillary Reflex Dilation
研究概览
简要总结
In this study, the pupillary dilation reflex is measured as a nociceptive indicator during elective abdominal surgery under general anesthesia.
详细描述
An infrared camera of the video pupillometer measures the pupillary dilation reflex (PDR) in response of a nociceptive stimulus. This autonomic reflex, parasympathetic mediated in sedated patients, can be generated by various pain stimuli (built in standardized protocol, surgical incision, ...) The PDR is a robust reflex, even in patients under general anesthesia, and provides a potential evaluation of the autonomous circuit within the nociceptive evaluation based on pupil dilation upon A-delta and C fibers in both electrical or mechanic stimulation. This mono-centric project involving American Society of Anesthesiologists (ASA) classification I-II patients undergoing elective abdominal surgery under general anesthesia are recruited. Enrolled patients perioperative undergo PDR measurements at four different standardized times.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled abdominal surgery
排除标准
- •History of eye deformity, invasive ophthalmologic surgery, impaired pupil reflex in advance
- •Kown cranial nerve(s) deficit
- •Infection of the eye
- •Predicted difficult airway management (DAF Guidelines)
- •Chronic opioid use (>3 months)
- •Ongoing treatment with beta-blockers, dopamine antagonists, topical atropine
研究组 & 干预措施
Pupil dilation reflex measurement
Four measurements of PDR during surgery at standardized times
干预措施: Pupil dilation reflex measurement (Device)
结局指标
主要结局
Pupillary Reflex Dilation
时间窗: Perioperative phase
Pupillary Reflex Dilation is measured four times intraoperatively as a possible indicator of success of analgesia
次要结局
- Patient Movement(Perioperative phase)
- Vital signs(Perioperative phase)
研究者
Davina Wildemeersch
MD
University Hospital, Antwerp