NCT01882270已完成不适用
Pericoronitis; Oral and Systemic Inflammation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 115
- 试验地点
- 1
- 主要终点
- Quality of Life
研究概览
简要总结
The purpose of this research study is to find out if the infection around 3rd molars and the resulting inflammation around the gum also produces a general systemic inflammation.
详细描述
Relate signs and symptoms of mild pericoronitis, an oral clinical condition characterized by intense inflammation and pain around a lower 3rd molar, to indicators of oral and systemic inflammation in patients seeking treatment for the condition.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Mild signs/symptoms of pericoronitis affecting at least one lower 3rd molar with adjacent 2nd molar (spontaneous pain with localized swelling, purulence/drainage) with recommended treatment being removal of 3rd molars,
- •Age 18 - 35 years,
- •ASA I, II health status,
- •AAP 1-3 periodontal status,
- •Willingness to participate in the study,
- •Geographic proximity to UNC.
排除标准
- •Major signs/symptoms of pericoronitis (Temperature >101 , dysphagia, limited mouth opening <20mm incisor, facial swelling/cellulitis, severe uncontrolled discomfort),
- •ASA III, IV health status,
- •Medical contraindication to full mouth periodontal probing,
- •AAP 4 periodontal status,
- •Antibiotic treatment within the past 2 months,
- •Current tobacco use,
- •BMI > 29,
- •Pregnancy,
- •Non English speaking.
结局指标
主要结局
Quality of Life
时间窗: one year
HRQOL data each day for seven days: Subject diary Pain 7pt Likert scale for worst/average pain in past 24h Gracely Scales for current sensory perception/affect Lifestyle, oral function, other symptoms 5pt Likert type scale Global QOL OHIP 14
次要结局
- inflammatory mediators(one year)
研究者
研究点 (1)
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