Lipid Profile and Oxidative Stress Parameters of Patients With Idiopathic Hypogonadotropic Hypogonadism and the Change of These Parameters With Gonadotropin Replacement Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 主要终点
- oxidative stress after hCG and HMG treatment
研究概览
简要总结
Effects of gonadotrophin replacement therapy Lipid Profile and Oxidative Stress Parameters of Patients with Idiopathic Hypogonadotropic Hypogonadism
详细描述
30 male patients diagnosed with IHH and a control group of 20 healthy cases with similar age and BMI were included in the study. The levels of advanced oxidation protein products (AOPP), thiol, malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8-OHdG) and the levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-K), low density lipoprotein (LDL-K), Apolipoprotein A1 (ApoA1) and Apolipoprotein B100 (ApoB100) were measured before and after gonadotrophin therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 22 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Serum testosterone concentration < 300ng/dL Absence of a pituitary or hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -
排除标准
- •diabetes mellitus, arterial hypertension other hormone deficiencies
研究组 & 干预措施
Hypogonadotropic hypogonadism patients
30 patients with idiopathic hypogonadotrophic hypogonadism
干预措施: human chorionic gonadotropin, human menopausal gonadotropin (Drug)
结局指标
主要结局
oxidative stress after hCG and HMG treatment
时间窗: 2010-2012
HDL levels after hCG treatment
时间窗: 2010-2012
total cholesterole levels after hCG treatment
时间窗: 2010-2012
次要结局
未报告次要终点
研究者
Aydogan Aydogdu
MD
Gulhane School of Medicine