跳至主要内容
临床试验/NCT06434870
NCT06434870招募中不适用

Comparison of the Effect of Spinal Anesthesia Applied in Elective Cesarean Cases on Frontal QRS Angle in Anemic and Non-Anemic Patients

Sanliurfa Mehmet Akif Inan Education and Research Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2024年4月20日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
100
试验地点
1
主要终点
The measurements to be taken include QRS, frontal QRS, QRS angle and Tp-e interval.(T4)

研究概览

简要总结

The QRS-T angle represents a novel marker of myocardial repolarisation. It is defined as the angle difference between the direction of ventricular depolarisation (QRS wave) and the direction of ventricular repolarisation (T wave). It is an indicator of instability in the electrophysiological properties of the myocardium and is associated with arrhythmias. The frontal QRS-T angle is a straightforward, cost-effective parameter that can be readily obtained from 12-lead electrocardiography.

The most prevalent arrhythmias during pregnancy are atrial arrhythmias. However, ventricular tachyarrhythmias are exceedingly rare during pregnancy and may be life-threatening.

Caesarean section is one of the most common surgical procedures. General anaesthesia, spinal anaesthesia and epidural anaesthesia can be employed in these patients. Spinal anaesthesia is a frequently employed method in caesarean section operations due to its rapid onset of effect, technical simplicity of application and higher probability of success.

In pregnant women, anaemia is defined as a haemoglobin concentration below 11 mg/dL in the first trimester, 11 mg/dL in the second trimester and 10.5 mg/dL in the third trimester.

详细描述

The QRS-T angle represents a novel marker of myocardial repolarisation. It is defined as the angle difference between the direction of ventricular depolarisation (QRS wave) and the direction of ventricular repolarisation (T wave). It is an indicator of instability in the electrophysiological properties of the myocardium and is associated with arrhythmias. The frontal QRS-T angle is a straightforward, cost-effective parameter that can be readily derived from 12-lead electrocardiography. The angle between the QRS and T waves is a useful indicator of myocardial repolarisation. It is associated with arrhythmias and instability in the electrophysiological properties of the myocardium. The frontal QRS-T angle is a simple, inexpensive parameter that can be easily obtained from 12-lead electrocardiography.

Pregnancy has a profound effect on the cardiovascular system. It results in an increase in blood volume, heart rate, venous pressure in the lower extremities, and cardiac output. Furthermore, it can result in a reduction in peripheral resistance and pulmonary vascular resistance, as well as a decline in blood pressure. Furthermore, it affects the cardiac conduction system, rendering patients more susceptible to arrhythmias. The most prevalent arrhythmias during pregnancy are atrial arrhythmias. Ventricular tachyarrhythmias are relatively uncommon during pregnancy and can be life-threatening.

One of the most common surgical procedures is caesarean section. General anaesthesia, spinal anaesthesia and epidural anaesthesia can be employed in these patients. Spinal anaesthesia is a frequently employed method in caesarean section operations due to its rapid onset of effect, technical ease of application and higher chance of success. In addition to the beneficial effects, direct cardiac and indirect cardiac side effects may be observed, such as vasodilatation due to sympathetic denervation, decreased right heart pressure and reflex bradycardia, which depend on the level of block.

In pregnant women, haemoglobin values below 11 mg/dL in the first trimester, 11 mg/dL in the second trimester and 10.5 mg/dL in the third trimester are considered to indicate anaemia.

The objective of this study was to investigate the effects of spinal anaesthesia in elective caesarean section cases on frontal QRS angle in anaemic and non-anaemic patients.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者
否

入选标准

  • •Aged 18-45 years
  • •Patients with American Society of Anesthesiologists (ASA) II classification

排除标准

  • •Patients with rhythm disorders
  • •Patients with electrolyte disturbances
  • •Patients with liver and/or renal failure
  • •Obese patients (body mass index > 30)
  • •Trauma patients
  • •Cancer patients
  • •ASA III-IV patients
  • •Patients who do not wish to participate in the study will be excluded.

结局指标

主要结局

The measurements to be taken include QRS, frontal QRS, QRS angle and Tp-e interval.(T4)

时间窗: 5 min after spinal anaesthesia

The measurements to be taken include QRS, frontal QRS, QRS angle and Tp-e interval.(T5)

时间窗: 10 min after spinal anaesthesia

The measurements to be taken include QRS, frontal QRS, QRS angle and Tp-e interval. (T1)

时间窗: preoperatively

The measurements to be taken include QRS, frontal QRS, QRS angle and Tp-e interval.(T2)

时间窗: after spinal anaesthesia

The measurements to be taken include QRS, frontal QRS, QRS angle and Tp-e interval.(T3)

时间窗: 5 min after spinal anaesthesia

次要结局

未报告次要终点

研究者

发起方
Sanliurfa Mehmet Akif Inan Education and Research Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

ahmet kaya

assistant professor

Sanliurfa Mehmet Akif Inan Education and Research Hospital

研究点 (1)

Loading locations...

相似试验