Role of Infant Feeding, Childhood Food Habits and Early Childhood Adiposity (RIF)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 115
- 主要终点
- Change in Infant Weight-for-Age Z-score over time by group
研究概览
简要总结
Rapid growth early in infancy is a risk factor for obesity and cardiovascular disease later in the lifespan. Evidence is limited, but both pre- and postnatal factors are associated with early rapid growth, and include high maternal BMI prior to pregnancy and excessive gestational weight gain. This research focuses on aspects of early feeding as potentially modifiable factor affecting early infant weight gain. Formula feeding mothers are randomized to receive either 5 oz of 8 oz bottles to use in feeding their infants from 2- to 16 weeks postpartum. In addition, a reference group of exclusively breastfeeding mother-infant dyads are also included. The hypothesis is that differences in feeding practices will be associated with differences in growth and that infants randomized to be fed from smaller bottles will grow more slowly that those randomized to larger bottles. Growth patterns of formula fed infants will also be compared to those of exclusively breastfed infants.
详细描述
Mothers complete feeding logs, questionnaires on health history, demographics, feeding attitudes and practices. Infant growth and body composition are measured via PEA POD, and maternal anthropometrics and body composition are measured in BOD POD the laboratory at 2, 8, and 16 weeks postpartum. Primary outcome is change in weight-for-age z-scores.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •pregnant or newborn aged 28 days or younger
排除标准
- •gestational diabetes, hypertension, pregnancy/delivery complications, premature birth, low birth weight
研究组 & 干预措施
Breastfeeding
control group
5 oz bottle
Subject will feed infant with 5oz medela bottle
干预措施: Feeding and growth differences, 5oz vs 8oz bottle (Behavioral)
8 oz bottle
Subject will feed infant with 8oz medela bottle
干预措施: Feeding and growth differences, 5oz vs 8oz bottle (Behavioral)
结局指标
主要结局
Change in Infant Weight-for-Age Z-score over time by group
时间窗: 2, 8 and 16 weeks of age
Infant weight (kg) (PEA POD scale) will be measured at each of three time points (2, 8, 16 weeks of age). Weight-for-Age Z-score (WAZ) will be calculated based on World Health Organization Global Database on Child Growth, means will be calculated and compared.
次要结局
未报告次要终点
研究者
Leann Birch
William P. Flatt Professor
University of Georgia
