Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 140
- 试验地点
- 2
- 主要终点
- Ongoing pregnancy rate
研究概览
简要总结
The purpose of this study is to determine if cryopreservation at the blastocyst stage followed by embryo thaw and transfer is as effective as cryopreservation of bipronuclear oocytes followed by post-thaw extended culture (PTEC), and blastocyst transfer. Effectiveness will be measured by the rate of ongoing pregnancy at 10 weeks gestation.
详细描述
Subjects will be randomized to one of two study groups during their cycles of in vitro fertilization (IVF). In one group, the subjects will have all of their embryos cryopreserved at the blastocyst stage, followed by thaw and transfer in a subsequent cycle. In the other group, subjects will have all of their embryos cryopreserved at the bipronuclear oocyte stage, followed by thaw, extended culture, and transfer in a subsequent cycle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female patient seeking autologous in vitro fertilization (IVF) treatment.
- •Cycle day 3 serum concentration of follicle stimulating hormone (FSH) less than 10.0 IU/l.
- •Baseline total antral follicle count observed on ultrasound with at least eight antral follicles.
- •18 to 40 years of age.
- •Ability to read and understand English.
排除标准
- •Embryo biopsy (a.k.a. pre-implantation genetic diagnosis (PGD)).
- •Any condition that, in the opinion of the physician or principal investigator, would place the patient at undue risk under this protocol or would otherwise make the protocol inappropriate for that subject.
- •No minors will be enrolled in this study.
结局指标
主要结局
Ongoing pregnancy rate
时间窗: 10 weeks gestation
Ultrasonically confirmed fetal heart motion at 10 weeks gestation
次要结局
未报告次要终点
研究者
Bruce Shapiro M.D.
Medica Director
Fertility Center of Las Vegas