Muscle Evaluation Using Ultrasound in the Critically Ill : ULTRAMUSCLE Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Ultrasound characteristics of the quadriceps
研究概览
简要总结
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction.
Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients.
The aim of the present study is to constitute an image bank and to describe the muscle mass and function recovery in critically ill patients.
详细描述
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction.
Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients.
The aim of the present study is to constitute an image bank and to describe the mass and function recovery in critically ill patients.
Ultrasound and clinical data will be collected and analysed during the ICU stay.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Critically ill patients with at least one organ failure defined, organ failure being defined by a SOFA equal or above 3 for the organ, and an expected duration of ICU stay equal of above 3 days
- •Exclusion criteria:
- •Pregnancy, age below 18, absence of consent
排除标准
- 未提供
结局指标
主要结局
Ultrasound characteristics of the quadriceps
时间窗: Since admission at day 0 and measured repetitively by 48 hours untildischarge from ICU or date of death from any cause, whichever came first, assessed up to day 28
Changes in ultrasound characteristics of the quadriceps : cross sectional area of quadriceps (cm2)
次要结局
未报告次要终点