Evaluation of Intramyocellular Lipid Content (IMCL) in Skeletal Muscle by Magnetic Resonance Spectroscopy
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- absolute change in intramyocellular lipid quantity with exercise
研究概览
简要总结
Type 2 diabetes is a growing public health issue and one component of Type 2 diabetes is 'insulin resistance" - the ability of insulin to work less well. The skeletal muscle is one of the largest users of sugar in the body, when the skeletal muscle is "insulin resistant", this contributes to diabetes. There is some evidence that the amount of fat in the skeletal muscle is related to the amount of insulin resistance. We are asking people to participate in a study to look at the amount of fat in muscle and how this fat amount changes with exercise. We hypothesize that heavier people will have higher amounts of fat and deplete this fat more slowly than lean subjects.
详细描述
High intramyocellular lipid (IMCL) content in skeletal muscle has been correlated to insulin resistance in obese subjects. Yet, endurance athletes have high intramyocellular lipid content and very low insulin resistance. There are several explanations for this paradox. This study will use a new magnetic resonance imaging technique to look at the amount of fat in the muscle and its depletion with exercise. We hypothesize that overweight subjects will have higher amounts of fat and deplete this fat more slowly than lean subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age range will be from age 18 to
- •We will be limiting the upper age range because increased age is associated with sarcopenia and alteration of fiber type.
- •We will define the lean trained group by a BMI of < 24 kg/m
- •We will define the overweight group as BMI > 26 25 kg/m
- •The subjects should be participating in regular running exercise (> 30 min/day, ≥ 5 days/week).
- •Weight must be stable [+/- 5 pounds] for at least the three months prior to the study for all participants.
排除标准
- •The subjects must not be on medications that may affect lipid levels, specifically lipid lowering agents, birth control pills, or diuretics.
- •The subjects should not be on a high fat diet (> 45% fat) as measured by a screening questionnaire.
- •The subject must not have any contraindications to magnetic resonance imaging.
结局指标
主要结局
absolute change in intramyocellular lipid quantity with exercise
时间窗: over 4 months
次要结局
未报告次要终点