Diet and Stool Metabolites in Women With Fecal Incontinence
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Stool butyrate levels
研究概览
简要总结
Fecal Incontinence (FI) is a debilitating and common condition with a prevalence ranging from 7-15% in community dwelling women. FI has an immense impact on quality of life and is associated with increased care giver burden, increased rates of institutionalization, and significant cost burden in older women. Traditionally believed to be primarily caused by child birth injury, recent studies show that the typical age of onset of FI is age 40 which is remote from child birth. Treatment options for FI are limited because the mechanism underlying FI in older women are poorly understood. The overriding goal of this project is to investigate the relationship between diet, stool metabolites and fecal incontinence.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age greater than 18,
- •parous women with fecal incontinence (defined as any uncontrolled loss of liquid or solid fecal material that occurs at least monthly over the last 3 months that is bothersome enough to desire treatment),
- •current negative colon cancer screening
排除标准
- •Current bloody diarrhea,
- •current or past diagnosis of colorectal or anal malignancy,
- •diagnosis of inflammatory bowel disease,
- •recent antibiotic treatment,
- •history of immune deficiency diseases,
- •history of recent treatment with immune suppressant medications.
结局指标
主要结局
Stool butyrate levels
时间窗: within 1 week of collection
Pattern of dietary intake by indicator
时间窗: 1 year
次要结局
- Stool levels of global metabolites(within 1 week of collection)