Stroke Registration of Young Adults in China
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Post-stroke disability
研究概览
简要总结
This is a multi-center, prospective,continuous registry study. The investigators will include 3000 young adult (18-45 years old) patients with confirmed first-ever acute ischemic stroke in China. The main purpose of this study is to build the study cohort of young ischemic stroke patients in China, and to compare the prognosis and stroke recurrence of young patients with different ischemic stroke subtypes. Secondary objectives are trying to find biomarkers of stroke recurrence.
详细描述
Approximately 10%-14% of all ischemic strokes occur in young adults ages 18 to 45 years old. Stroke etiology in this population differs by geographic region and has greater heterogeneity than in older individuals. Ascertain the definite etiologic classification in this young patients might be the key point to prevent the stroke recurrence and reduce the stroke burden. Advances in stroke diagnostic tests, particularly neuroimaging, refinement in classification schema. In this multi-center registry study conducted in China, we determine to explore the difference of prognosis and stroke recurrence of young patients with different ischemic stroke subtypes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 through 45 years, both genders
- •First-ever acute ischemic stroke
- •Onset of symptoms within 72 hours of inclusion
- •Willing to participate in follow-up visits
排除标准
- •Silent stroke
- •Failure to give their informed consent
结局指标
主要结局
Post-stroke disability
时间窗: 3 months
Modified Rankin Scale score changes (continuous) and dichotomized at percentage with score 0-2 vs. 3-6 at 3-month follow-up.
Stroke recurrence
时间窗: 1 year
Percentage of patients with the 1 year new vascular events, defined as any event of the following: Any stroke (ischemic or hemorrhage)
次要结局
- Cardiovascular death(3 months, 6 months and 1 year)
- Other systemic embolism(3 months, 6 months and 1 year)
- Other cardiovascular event(3 months, 6 months and 1 year)
研究者
Yi Yang
Associate dean, Director of Cerebrovascular Disease Center
The First Hospital of Jilin University