NL-OMON32697已完成不适用
Circadian Influence on Renal Clearance of Aminoglycosides in cystic fibrosis patients - CIRCA
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age: * 18 years
- •- a diagnosis of cystic fibrosis (ie, sweat chloride *60 mmol/L or a genotype associated with cystic fibrosis)
- •- chronic infection with Pseudomonas aeruginosa with the most recently isolated organism showing sensitivity to tobramycin.
- •- Pulmonary exacerbation as defined by Fuchs and colleagues.
排除标准
- •- use of nephrotoxic drugs (NSAID*s, furosemide, vancomycin)
- •- allergy for aminoglycosides
- •- granulocytopenia (<1,0 x 109/L)
- •- pregnancy
- •- calculated GFR < 40 ml/min
- •- pre-existing hearing impairment ( * 20 dB hearing level at any two frequencies between 2kHz and 8 kHz on the standard audiogram)
研究者
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