Relationship Between Genetic Polymorphism and Postoperative Nausea and Vomiting Undergoing Breast Surgery With General Anesthesia in Chinese Han Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 568
- 主要终点
- Whether the participants occur nausea or not
研究概览
简要总结
Postoperative nausea and vomiting ( PONV ) is one of the common complications after general anesthesia while genetic factors may play an important role in Postoperative nausea and vomiting. In this study, the investigators investigated the relationship between gene polymorphism ( such as single nucleotide polymorphism ) of the gene HTR3A ( 5-hydroxytryptamine receptor 3A ), HTR3B ( 5-hydroxytryptamine receptor 3B ), HTR3C ( 5-hydroxytryptamine receptor 3C ) and TACR1 ( tachykinin receptor 1 ) etc. with nausea and vomiting after general anesthesia. Simultaneously, the investigators explored the influencing factors of nausea and vomiting.
详细描述
Materials and methods:
Demographic data and risk factors responsible for PONV, including the history of PONV and motion sickness, were collected preoperatively by interviewing participants the day before anesthesia.
All study subjects received a standardized anesthesia regimen. General anesthesia was induced by midazolam 0.04 mg/kg, propofol 1.5 mg/kg, sufentanil 0.4 μg/kg, and cisatracurium 0.2 mg/kg (to facilitate tracheal intubation) given intravenously.Participants' lungs were ventilated with 50% oxygen in air.
During general anesthesia, concentration of sevoflurane maintained 1.0% to 3.0% at the discretion of anesthetist who was not involved in the study. General anesthesia also uses propofol 1 mg kg-1 h-1 and sufentanil 0.1 μg kg-1 h-1 by continuous intravenous infusion. An Entropy index monitor was used to maintain the appropriate anesthesia depth by 40-60. Participants received a repeated bolus of sufentanil 0.1 μg/kg or cisatracurium intravenously on demand.
After surgery the investigators recorded the data such as Anesthesia duration, doses of sufentanil and propofol and so on.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Undergoing breast surgery with general anesthesia
- •American Society of Anesthesiologists Physical Status Classifications 1-2
- •No history of smoking
- •body mass index (BMI) <35 kg/m2
排除标准
- •Declined to participate
- •Had used antiemetics, steroids, H2 antagonists, anticholinergics, antihistamines, butyrophenones, phenothiazines, metoclopramide or opioids within 24 hours
- •Gastroesophageal reflux, gastrointestinal obstruction or ulcer, vestibular or hearing dysfunction
- •Liver impairment, renal impairment, psychiatric disorder, chronic pain
- •Pregnant and lactating patients
- •Requiring postoperative patient-controlled analgesia
- •Requiring prophylactic use of antiemetics
- •Allergic to drugs related in the study
- •Receiving chemotherapy within one week before surgery
结局指标
主要结局
Whether the participants occur nausea or not
时间窗: Period of 6 to 24 hours after surgery
Nausea was defined as a feeling of wanting to throw up or about to throw up.
Whether the participants occur vomiting or not
时间窗: Period of 6 to 24 hours after surgery
Vomiting was defined as the discharge of the stomach contents, while retching as an involuntary attempt to vomit that did not produce stomach contents. Retching was considered as vomiting.
次要结局
- Level of nausea(Within 24 hours after surgery)
- Number of vomiting(Within 24 hours after surgery)