Lung Recruitment Improves Right Ventricle Performance After Cardio-Pulmonary Bypass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 主要终点
- Right ventricle assessment by transesophageal echocardiography
研究概览
简要总结
This study test whether a lung recruitment maneuver improves the right ventricle performance after cardiopulmonary bypass. Half of the patients received an standard protective ventilation and the other half the same ventilatory pattern after a lung recruitment maneuver.
详细描述
Atelectasis is developed in 90% of anesthetized patients after surgery.
Protective ventilation with low tidal volumes and positive-end expiratory pressure (PEEP) promotes atelectasis with the potential right ventricle dysfunction induced by the increment in afterload (activation of the pulmonary hypoxic vasocontriction reflex).
Lung recruitment can improve the right ventricle performance caused by atelectasis because the pulmonary hypoxic vasocontriction reflex desapear in a normal aerated lungs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •cardiovascular surgery with cardiopulmonary bypass.
- •Patients with a New York Heart Association (NYHA) class I-II,
- •Pre-operative left ventricular ejection fraction ≥ 50 %.
- •Euroscore ≤ 6.
排除标准
- •TEE contraindications.
- •Hemodynamically unstable
- •Needi for inotropic support
结局指标
主要结局
Right ventricle assessment by transesophageal echocardiography
时间窗: intraoperative
次要结局
- Atelectasis assessment by transesophageal echocardiography(intraoperative)
- PaO2 and respiratory compliance(intraoperative)
研究者
Silvina Longo
Medical Doctor
Hospital Privado de Cordoba, Argentina