Alterations of Glycocalyx in Critical Illness and During Major Surgery and Approaches for Glycocalyx Protection. Effect of Parenteral Nutrition and Plasma Lipidome on GCX
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Endothelial Glycocalyx Thickness
研究概览
简要总结
Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx.
The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled.
Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients in ICU
- •indication for lipid administration as a part of TPN
排除标准
- •shock or clinical/laboratory signs of tissue hypoperfusion
- •previous lipid infusions (within 3 months before entering study)
- •hyperlipidaemia
- •hyperglycaemia (over 10 mmol/l)
- •current or previous (within 72 hours before entering the study) use of propofol
- •pancreatitis
- •severe liver failure
- •current use of statins
结局指标
主要结局
Endothelial Glycocalyx Thickness
时间窗: One week within the ICU care
Endothelial glycocalyx thickness was measured indirectly by PBR, which is a lateral movement of the red blood cells from the median column in the microcirculation in micrometers. The higher the PBR is the more damaged the endothelial glycocalyx is.
次要结局
未报告次要终点
研究者
Vladimir Cerny
Clinical Professor
University Hospital Hradec Kralove