Multicentre Pre-operative Prehabilitation to Reduce Surgical Complications in Patients undergoing Major Upper GI Resections.

Hunter New England Local Health District0 个研究点目标入组 200 人开始时间: 2019年8月9日最近更新: 2022年9月5日

试验速览

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•Aged 18 years and over
•- Written informed consent
•- Operative procedure planned at least 4 weeks from randomisation date
•Patient must be assessed as fit for surgery by the treating Surgeon based on past medical history and CPET testing.
•- Patient must be undergoing a major upper gastrointestinal surgical procedure with neoadjuvant therapy including the following:
•* Oesophagectomy
•* Total/ Subtotal Gastrectomy
•* Pancreaticoduodenectomy
•* Major Liver Resection( >2 segments)

•Unresectable/ metastatic disease at any point within the study
•- Progressive disease during neoadjuvant chemotherapy
•- Known Class III/IV heart failure or moderate to severe pulmonary hypertension
•- Poorly controlled cardiac arrhythmia/ excluded by an anaesthetist or a cardiologist
•- Uncontrolled hypertension >180/100
•- Claudication
•- Vascular aneurysm
•- Severe COPD with FEV1<50% predicted
•- For safety reasons, the study cannot enrol people who don’t speak basic English as in a maximal intensity exercise program we cannot provide a safe environment without a trained, NSW Health registered translator for every exercise session.
•- Clinical decision by treating Surgeon that operative procedure will be scheduled less than 4 weeks

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