Primed vs Unprimed Facilitatory and Depressive Paired Associative Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 主要终点
- Change from baseline resting motor threshold
研究概览
简要总结
Following brain injury (e.g. stroke), application of non-invasive brain stimulation may improve rehabilitative efforts. However, the most effective method of non-invasive brain stimulation is unknown. Paired associative stimulation (PAS) is a method of non-invasive brain stimulation that pairs an electrical peripheral nerve stimulus with a magnetic stimulus to the head. This method can be applied in a manner that increases (facilitates) or decreases (depresses) excitability within the brain. Furthermore, applying two consecutive PAS sessions within minutes of each other (called primed PAS) may augment changes in excitability more than a single PAS session alone.
Thus, the purpose of this study is to compare the effect of a double PAS session (primed PAS) to the effect of a single PAS session (unprimed PAS) and a sham PAS session in healthy individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Device Feasibility
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •≥ 18 and ≤ 30 years of age
- •Elicitable motor evoked potential from the motor cortex contralateral to the dominant hand
- •Elicitable N20 sensory evoked potential
排除标准
- •History of neurological disease
- •Seizure within the past 2 years
- •Currently taking epileptogenic medication
- •Peripheral neuropathy
- •Cognitive impairment and/or major psychiatric disorder
- •Metal in the head (dental permitted)
- •Pacemaker or other indwelling devices
- •Pregnancy
研究组 & 干预措施
Primed PAS 1A
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
干预措施: Transcranial Magnetic Stimulation (Magstim) (Device)
Unprimed PAS 1B
A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
干预措施: Transcranial Magnetic Stimulation (Magstim) (Device)
Sham PAS
A single session of sham paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied
干预措施: Transcranial Magnetic Stimulation (Magstim) (Device)
Primed PAS 2A
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
干预措施: Transcranial Magnetic Stimulation (Magstim) (Device)
Unprimed PAS 2B
A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
干预措施: Transcranial Magnetic Stimulation (Magstim) (Device)
Primed PAS 1C
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
干预措施: Transcranial Magnetic Stimulation (Magstim) (Device)
Primed PAS 2C
Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
干预措施: Transcranial Magnetic Stimulation (Magstim) (Device)
结局指标
主要结局
Change from baseline resting motor threshold
时间窗: Immediately before and within 60 minutes following intervention
Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The lowest stimulator output needed to elicit a consistent response will be recorded.
Change from baseline peak-to-peak amplitude of motor evoked potential
时间窗: Immediately before and within 60 minutes following intervention
Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The peak-to-peak amplitude of the EMG response will be measured.
次要结局
未报告次要终点