Protein S Activity in Women With Unexplained Infertility
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 主要终点
- Protein S activity
研究概览
简要总结
This study will add:
Finding out an association between Protein S activity and unexplained female infertility.
Aim:
Study hypothesis:
In women with unexplained infertility protein S activity may be low.
Study question:
In women with unexplained infertility does protein S activity low?.
This study aims to assess the activity of protein S activity in women with unexplained infertility.
Objectives:
The main objective of this study is:
To determine the prevalence of Protein S activity with unexplained female infertility and to compare its prevalence in fertile women among women attending outpatient clinics at Ain Shams University Maternity Hospital.
详细描述
- Type of Study: Case Control Study.
- Study Setting: Ain Shams University Maternity Hospital: outpatient Infertility clinic and outpatient gynecology clinic.
- Study Population: The study will include women with unexplained infertility (Group 1; cases) and fertile women who got pregnant and delivered at least once in the previous year with no history of recurrent abortions nor history of secondary infertility (Group 2; control).
Group 1: Will include 30 women with unexplained primary infertility; will be recruited from the outpatient infertility clinic.
Group 2; another 30 fertile women who got pregnant and delivered at least once in the previous year with no history of recurrent abortions; will recruited from outpatient gynecology clinic as control.
According to inclusion and exclusion criteria listed below.
Inclusion criteria:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age: 18 - 35 years old.
- •Normal husband's semen analysis, (WHO criteria):
- •Count ≥ 15 million/ml.
- •Motility: ≥ 40%
- •Morphology: ≥ 4% normal morphology.
- •Documented ovulation.
- •Normal Follicle Stimulating Hormone, Luteinizing Hormone, Thyroid Stimulating Hormone, serum prolactin.
- •Patent Fallopian tubes.
- •Normal uterine cavity.
排除标准
- •Patients aged less than 18 years or more than 35 years old.
- •Secondary infertility
- •Presence of male factor infertility
- •Anovulatory cycles.
- •Tubal block; Tubal disease is an important cause of infertility and should be specifically excluded.
- •Medical disorder that might affect pregnancy (e.g.: Diabetes, Thyroid dysfunction)
- •Patients with recurrent abortion. -
结局指标
主要结局
Protein S activity
时间窗: six months
venous blood sample
次要结局
未报告次要终点
研究者
Esraa Gamal Ahmed
Esraa Gamal Ahmed
Ain Shams Maternity Hospital