Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Cardiac troponin I
研究概览
简要总结
Calcified aortic valve stenosis (CAVS) is a progressive disease and nowadays, the cornerstone in diagnostics and follow-up is echocardiography. Cardiac biomarkers (such as cardiac troponins T and I and NT-pro-BNP) hold promise to fulfil a role in early recognition of complications concerning the aortic valve and decompensation. For this purpose, it is important to assess the normal biological variation (BV) of cardiac biomarkers in CAVS. The assessment of biological variation will contribute to a better understanding of fluctuation of cardiac biomarkers in subjects with stable CAVS. These data will improve monitoring of CAVS using cardiac biomarkers.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinically stable moderate aortic valve stenosis
- •No evidence of acute cardiovascular disease
排除标准
- •Acute myocardial infarction in the last six months
- •Pulmonary embolism in the last six months
- •Hospitalisation for heart failure in the last six months
- •Chronic kidney disease
结局指标
主要结局
Cardiac troponin I
时间窗: One year
NT-pro-BNP
时间窗: One year
Cardiac troponin T
时间窗: One year
次要结局
未报告次要终点