Implementation of Computerized Clinical Decision Support for Mechanical Ventilation of Patients With Acute Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 350
- 试验地点
- 2
- 主要终点
- LTVV Compliance
研究概览
简要总结
Perform a pilot study of quality improvement interventions for critical care physicians (intensivists) and respiratory therapists (RTs) to improve application of low tidal volume mechanical ventilation (LTVV) for patients with the acute respiratory distress syndrome (ARDS) using the computerized mechanical ventilation protocols currently available in the investigator's Cerner electronic health record (EHR).
详细描述
A multidisciplinary team of implementation researchers and clinical effectiveness researchers has been assembled to adapt the Consolidated Framework for Implementation Research (CFIR) for this planning study. The team identified the baseline clinical care delivery for LTVV in patients with ARDS across Intermountain hospitals and identified the barriers and facilitators to this standard of care. This pilot implementation study will focus on a Pilot Solution aimed at achieving ideal clinical care delivery of LTVV for patients with ARDS.
Abbreviations for Mechanical Ventilation:
PEEP: positive end expiratory pressure FIO2: fraction of inspired oxygen CPAP: continuous positive airway pressure PS: pressure support VC: volume control VC+: hybrid mode for volume targeted ventilation on Puritan Bennett ventilators PRVC: pressure regulated volume control, hybrid mode for volume targeted ventilation on Draeger ventilators PF ratio: ratio of partial pressure of arterial oxygen (PaO2 mmHg) divided by the FIO2 expressed in liters
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Invasive mechanical ventilation
- •PF ratio <255
- •Bilateral infiltrates on chest radiograph (adjudicated by a co-investigator)
- •Presence of ≥1 risk factor for ARDS as determined by review of the HER
排除标准
- •Age <18 years
- •Pulmonary capillary wedge pressure >18 mm Hg if a right heart catheter is present
- •Known to be pregnant
- •Death <24 hours from initial intubation
- •Placed comfort care <24 hours from initial intubation
- •Mechanically ventilated for >7 days prior to meeting ARDS criteria
结局指标
主要结局
LTVV Compliance
时间窗: through study completion - 6 months
Defined as: % of time each patient is on a compliant tidal volume for the duration of mechanical ventilation. Measured as: VC, PRVC, or VC+ with volume set to 6.5 ml/kg or less for each patient (proportion of mechanically ventilated hours, excluding hours on appropriate CPAP/PS)
次要结局
- Utilization of Ventilation Protocol (continuous)(through study completion - 6 months)
- Ventilator-Free Days (VFD) to Day 28(through study completion - 6 months)
- % of Patients who do not survive to day 28(through study completion - 6 months)
- PEEP FI02 Compliance (continuous variable)(through study completion - 6 months)
- Utilization of Oxygenation Protocol (continuous)(through study completion - 6 months)
- LTVV Compliance >90% (binary)(through study completion - 6 months)
- PEEP FI02 Compliance >70% (binary)(through study completion - 6 months)