Observational Evaluation of the Relationship Between Intraoperative Processed EEG Monitoring,Surgical Bleeding and Recovery Quality in Patients Undergoing Rhinoplasty Under Controlled Hypotension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Intraoperative qCON and qNOX values during controlled hypotension
研究概览
简要总结
This prospective observational study evaluates intraoperative processed electroencephalography parameters in adult patients undergoing elective rhinoplasty under total intravenous anesthesia with controlled hypotension. The study focuses on qCON and qNOX values during anesthesia, their relationship with early postoperative recovery, and their association with intraoperative surgical bleeding and surgical field quality.
详细描述
Controlled hypotension is commonly used during rhinoplasty to improve surgical field visibility and reduce bleeding. However, the adequacy and safety of controlled hypotension should not be evaluated only by hemodynamic variables. Processed EEG monitoring may provide additional information about hypnotic depth and the probability of response to nociceptive stimulation.
In this prospective observational study, adult patients undergoing elective rhinoplasty under general anesthesia were monitored with standard ASA monitoring and processed EEG monitoring. Total intravenous anesthesia was maintained with propofol and remifentanil. Esmolol infusion was used as part of the controlled hypotension strategy. Intraoperative qCON and qNOX values, hemodynamic parameters, surgical bleeding scores, anesthetic drug consumption, extubation time, time to reach Aldrete score ≥9, and early postoperative cognitive recovery were recorded.
The primary objective is to evaluate the intraoperative course of qCON and qNOX values during controlled hypotension. Secondary objectives are to assess the relationship of processed EEG parameters with recovery quality, early postoperative cognitive status, anesthetic drug consumption, and surgical field bleeding.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 years or older
- •Patients scheduled for elective rhinoplasty
- •Patients classified as ASA physical status I-II
- •Patients planned to undergo general anesthesia with total intravenous anesthesia
- •Patients in whom frontal processed EEG electrodes can be applied
- •Patients who provide written informed consent
排除标准
- •Emergency surgery
- •Severe neurological disease
- •Scalp lesion or marked dermatitis preventing processed EEG electrode placement
- •Communication or hearing impairment preventing postoperative assessment
- •Marked hemodynamic instability
- •Multiple trauma or need for postoperative intensive care unit admission
- •Pregnancy
结局指标
主要结局
Intraoperative qCON and qNOX values during controlled hypotension
时间窗: From baseline before anesthesia induction until the end of surgery, up to approximately 150 minutes intraoperatively.
qCON and qNOX values obtained by processed EEG monitoring will be recorded at predefined intraoperative time points. qCON will be used as an index of hypnotic depth, and qNOX will be used as an index of the probability of response to nociceptive stimulation.
次要结局
- Heart rate during controlled hypotension(From baseline before anesthesia induction until the end of surgery, up to approximately 150 minutes intraoperatively.)
研究者
Elif KARAKAYA
principal investigator
Gazi University