An International Randomised Controlled Trial to Establish the Effects of Early Intensive Blood Pressure Lowering in Patients With Intracerebral Haemorrhage - INTERACT2

The National Health and Medical Research Council NHMRC of Australia0 个研究点目标入组 2,839 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1.Patient older than 18 years old (there is no upper age limit).
•2.Acute stroke syndrome due to spontaneous ICH, confirmed by clinical history and CT scan
•3.At least two systolic BP measurements of more than or equal to 150 mmHg and less than or equal to 220 mmHg, recorded 2 or more minutes apart.
•4.Able to commence randomly assigned BP lowering regimen within 6 hours of stroke onset.
•5.Able to be â??activelyâ?? treated and admitted to a monitored facility

•1.Clear indication or contraindication to intensive BP lowering.
•2.Evidence ICH secondary to a structural abnormality
•3.Recent (within 1 month) use of a thrombolytic agent
•4.Previous ischaemic stroke within 30 days
•5.A very high likelihood that the patient will die within the next 24 hours on the basis of clinical and/or radiological criteria
•6.Score of 3-5 on the Glasgow Coma Scale (indicating deep coma)
•7.Significant pre-stroke disability or advanced dementia
•8.Planned early neurological intervention
•9.Participation in another clinical trial.
•10.A high likelihood that the patient will not adhere to the study treatment and follow-up regimen.

发起方

The National Health and Medical Research Council NHMRC of Australia