Should Integrilin be an Integral Part of Adjunctive Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction?
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- All-cause mortality and composite or Q-wave myocardial infarction
研究概览
简要总结
The aim of this observational study is to evaluate the in hospital and 6 month outcomes of the use of Glycoprotein IIb/IIIa inhibitor eptifibatide as adjunctive therapy in patients undergoing primary Percutaneous Coronary Intervention for ST-elevation myocardial infarction in a large tertiary referral center.
It is hypothesized that Glycoprotein IIb/IIIa inhibitor use during primary Percutaneous Coronary Intervention for ST-elevation myocardial infarction/ acute myocardial infarction is superior to unfractionated heparin alone or bivalirudin alone. Additionally, after propensity matching this superiority remains.
详细描述
This is a retrospective, observational, data analysis of approximately 800 patients who underwent primary Percutaneous Coronary Intervention at our institution since September 2000. Patients will have either received eptifibatide pre-or during Percutaneous Coronary Intervention or have received no eptifibatide. Patients who received a thrombolytic prior to Percutaneous Coronary Intervention will be excluded.
This analysis is estimated to take 1-2 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Underwent Percutaneous Coronary Intervention at Washington Hospital Center since September 2000
- •Either received eptifibatide pre-or during PCI or have received no eptifibatide.
排除标准
- •Patients who received a thrombolytic prior to Percutaneous Coronary Intervention.
结局指标
主要结局
All-cause mortality and composite or Q-wave myocardial infarction
时间窗: Chart review 6 months after PCI
6-month rates of all-cause mortality and the composite of all-cause mortality or Q-wave myocardial infarction.
次要结局
- TIMI major bleeding(During hospital stay; average stay is less than 48 hours)