临床试验/NCT00167791

NCT00167791撤回不适用

Multicenter Trial Using Multi-dose Rituximab as Induction and Desensitization Therapy for Patients on the Waiting List for Kidney Transplant With a Positive Donor Specific Crossmatch to a Living Donor

University of Wisconsin, Madison2 个研究点分布在 1 个国家开始时间: 2005年7月最近更新: 2015年10月14日

适应症

试验速览

阶段: 不适用
状态: 撤回
发起方: University of Wisconsin, Madison
试验地点: 2
主要终点: Conversion of a positive donor specific cross-match to a living donor to a negative cross-match thereby allowing successful transplantation.

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This is a study of patients who have a high risk of kidney rejection before kidney transplant. The hypothesis is that treatment with a medication called rituximab will make it possible for them to receive a kidney transplant from a donor who previously did not present a good match.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Active status on a kidney transplant waiting list with positive cross match against a living donor

排除标准

•Receipt of a live vaccine within 4 weeks prior to randomization
•Previous Treatment with Rituximab

结局指标

主要结局

Conversion of a positive donor specific cross-match to a living donor to a negative cross-match thereby allowing successful transplantation.

时间窗: assess 4 weeks after Rituximab treatment completed

Transplant success or failure following the desensitization protocol.

时间窗: ongoing assessment for 2 years after transplant

次要结局

Decrease in incidence of humoral rejection to less than 50% at 1 year.(assess 1 year after transplant)

研究者

发起方

University of Wisconsin, Madison

申办方类型

Other

责任方

Sponsor

研究点 (2)

Loading locations...

相似试验

撤回

1 期

Rituximab Therapy for Patients on Kidney Transplant Waiting List With Positive Donor Specific Crossmatch to Living DonorKidney Insufficiency

NCT00476515Massachusetts General Hospital

终止

2 期

Desensitization of Highly Sensitized Deceased Donor Renal Transplantation CandidatesKidney Failure

NCT00986947Johns Hopkins University20

已完成

不适用

Rituximab administration before or after kidney transplantatioantibody-mediated rejection after kidney transplantation, ABO mismatched kidney transplantation, and recurrent post-transplant nephropathies

JPRN-UMIN000004344Department of Pediatrics, Kobe University Graduate School of Medicine10

终止

3 期

Efficacy of Rituximab in Acute Cellular Rejection in Renal Transplant PatientsAcute Rejection

NCT01117662Hannover Medical School13

已完成

2 期

Rituximab for the Primary Treatment of Denovo Extensive Chronic Graft Versus Host Disease (GVHD)Chronic Graft-versus-host Disease

NCT01161628Northside Hospital, Inc.25