One-Shot Ovarian Stimulation Protocol: A Pilot Study Investigating the Endocrine Profile
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 6
- 主要终点
- Estradiol
研究概览
简要总结
The current prospective observational pilot study aims to evaluate the endocrine profile of a single-injection protocol (single CFA + daily oral administration of CC).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •AMH (Anti-Mullerian Hormone) 1.2-3.5 ng/ml or AFC 7-20
- •No family history of hereditary or chromosomal diseases
- •Body mass index (BMI) 18 to 30 kg/m2
排除标准
- 未提供
研究组 & 干预措施
Corifollitropin alfa (CFA) 150 mcg + Clomiphene Citrate (CC) 100 mg/day from D1
干预措施: Monitoring cycle (Diagnostic Test)
Corifollitropin alfa (CFA) 150 mcg + Clomiphene Citrate (CC) 100 mg/day from D1
干预措施: Corifollitropin alfa (CFA) 150 mcg + Clomiphene Citrate (CC) 100 mg/day from D1 (Drug)
Corifollitropin alfa (CFA) 150 mcg + Clomiphene Citrate (CC) 100 mg/day from D1
干预措施: Clomiphene Citrate (CC) 100 mg/day from D1 (Drug)
结局指标
主要结局
Estradiol
时间窗: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
Estradiol levels
Progesterone
时间窗: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
Progesterone levels
Follicle stimulating hormone (FSH)
时间窗: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
FSH levels
Luteinizing hormone (LH)
时间窗: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
LH levels
次要结局
- Number of oocytes retrieved (COCs)(7 -20 days from initiation of ovarian stimulation)
- Days of stimulation(7 -20 days from initiation of ovarian stimulation)
- Number of MII oocytes(7 -20 days from initiation of ovarian stimulation)
- Follicular Output Rate (FORT)(7 -20 days from initiation of ovarian stimulation)
- Follicle-to-oocyte index (FOI)(7 -20 days from initiation of ovarian stimulation)
- Cancellation rate(7 -20 days from initiation of ovarian stimulation)
- Ovarian hyperstimulation syndrome (OHSS) rate(Until 15 days after punction)