The Shanghai Protocol for Early Enteral Nutrition in Mechanical Ventilated Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- energy target fulfilling rate
研究概览
简要总结
compare different enteral nutrition strategy in patients with mechanical ventilation
详细描述
There has been many evidence that deficiency in energy and protein take-in are associated with poor outcome in critical patients. To reach an adequate amount of energy and protein is critical in patients with respiratory failure and with mechanical ventilation, as it prevents muscle dystrophy and thus prevents ICU acquired weakness, leading to a better outcome in the end. Enteral Nutrition is preferred as it prevents gut dysfunction in respiratory failure patients, and may prevent further infection. But there are many challenge in implement a good enteral nutrition therapy, and energy or protein deficiency is common in patient with respiratory failure. There have been many protocols aiming at reaching enough enteral nutrition for ICU patients, most of which are based on a background of western and developed countries. The investigators developped a enteral nutrition protocol based on an unique cultural background of eastern developing country, trying to help the ICU patients reaching nutrition target, so that the patients may have better outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU patients
- •Receiving mechanical ventilation (MV) both Non-invasive ventilation and invasive ventilation
- •Expecting MV more than 72 hours
排除标准
- •Pregnancy
- •ICU stay < 72hr
研究组 & 干预措施
Standard care
Standard care: patients receive enteral nutrition in accordance with the usual practice in the participating units
干预措施: Standard care (Other)
Protocol care
Protocol care: patient receive enteral nutrition in accordance with enteral nutrition protocol studied
干预措施: Protocol care (Other)
结局指标
主要结局
energy target fulfilling rate
时间窗: 7 days from enrollment
the proportion of patients in both arms meeting the targeted energy in-take
protein target fulfilling rate
时间窗: 7 days from enrollment
the proportion of patients in both arms meeting the targeted protein in-take
次要结局
- mortality(28 days from enrollment)
