Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 主要终点
- Psychological assessment of patients with depressive disorders
研究概览
简要总结
This is a case control study including simple random cases of 90 persons, 45 of them have depressive disorders and the other 45 are healthy individuals,age group between 18-60 years old, cases will be recruited from outpatient psychiatric clinic in sohag university hospital, all cases will be exposed to psychological assessment and also laboratory assessment of kynurenine metabolites by using biokits
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 18 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age group 18: 60 years old
- •cases are drug free of at least 4 months
排除标准
- •patients with comorbid other psychiatric disorders( SUD,anxiety)
- •patients with IQ below 90
- •patients with psychotic features
- •patients with postpartum depression
- •patients with chronic medical illness that might affect immune function
- •patients under treatment with immune modulating therapy
结局指标
主要结局
Psychological assessment of patients with depressive disorders
时间窗: From the enrollment of all cases till three months later
All cases will be subjected to psychological assessment by using structured clinical interview for DSM-V to assess major depressive disorder,bipolar and other depressivedisorders, Hamilton depression rating scale HAN-D to assess MDD, Hamilton anxiety inventory HAM-A to assess anxiety disorders, Montreal cognitive assessment to assess cognitive functions, Pittsburg sleep quality index to assess quality of sleep and detailed family history will be obtained to assess possibility of genetic factors in health relatives to patients with depressive disorders.
Detect abnormalities in kynurenine pathway in patients with depressive disorders
时间窗: From the time of enrollment till 3 months later
Blood samples will be collected from patients and healthy control cases in microbiology laboratory in Sohag university hospital; by using biokits for kynurenine to measure kynurenine level in nanomolar to low micromolar in liter, Add a tryptophan measure outcome to measure tryptophan level in micromol per liter Add a quinolinic acid measure outcome to measure quinolinic acid level in microgram per milliliter by ELISA
次要结局
未报告次要终点
研究者
Samar Abdelsamie Asaad
Assistant Lecturer at Sohag university hospital
Sohag University