跳至主要内容
临床试验/CTRI/2024/02/062499
CTRI/2024/02/062499尚未招募不适用

A cross sectional study to determine usable semitendinosus tendon length in a cohort of patients undergoing anterior cruciate ligament reconstruction with hamstrings graft

All India Institute of Medical Sciences,Raipur1 个研究点 分布在 1 个国家目标入组 48 人开始时间: 2024年2月13日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
48
试验地点
1
主要终点
We expect that the usable length and diameter of the quadrupled semitendinosus tendon will be more than 600mm and 8 mm after resection of flat terminal portion and muscle belly and keeping the cross-sectional diameter with circular or oval

研究概览

简要总结

The anterior cruciate ligament (ACL) is one of a pair of cruciate ligaments (the other being the posterior cruciate ligament) in the human knee.The purpose of the ACL is to resist the motions of anterior tibial translation and internal tibial rotation; this is important to have rotational stability. This function prevents anterior tibial subluxation of the lateral and medial tibiofemoral joints. The ACL has mechanoreceptors that detect changes in direction of movement, position of the knee joint, and changes in acceleration, speed, and tension. A key factor in instability after ACL injuries is having altered neuromuscular function secondary to diminished somatosensory information. For athletes who participate in sports involving cutting, jumping, and rapid deceleration, the knee must be stable in terminal extension.The ACL can be injured or torn in a number of different ways. The most common mechanism is that of a sudden pivoting or cutting maneuver during sporting activity, which is commonly seen in football, basketball and soccer. The ligament can also tear due to work injuries or automobile accidents.At the time of the injury, a “pop” or “snap” can sometimes be felt or heard. The amount of pain experienced at the time of the injury is somewhat variable but can be quite severe. Typically, the person is unable to continue play or activity, and has the impression that a significant injury has occurred.

During ACL reconstruction surgery, a graft is used to replace the torn ACL. One option for the graft is to use the hamstring tendons, specifically the semitendinosus and gracilis tendons, which are located at the back of the thigh. These tendons are often selected due to their accessibility, strength, and potential for successful incorporation into the knee joint.The surgical procedure involves harvesting the hamstring tendons, usually through a small incision near the knee. The tendons are then prepared by removing any excess tissue and folded over to create a stronger graft. The graft is then inserted into the knee joint, passing through tunnels drilled in the tibia and femur, to mimic the function of the original ACL.

Graft strength is only one of the factors influencing anterior cruciate ligament (ACL) graft choice.However, it has a direct bearing on ultimate stability,which is the goal of ACL.Load to failure (LTF) is the parameter used to compare strenghth of graft.10-mm BPTB graft would be 110% as strong as the native ACL. A two-strand semitendinosus (ST) and two-strand gracilis (Gr) (2ST/2Gr)graft would be 238% as strong as the native ACL.A four-strand ST (4ST) would be 280% as strong as the ACL.Four-strand hamstring autografts are the strongest available grafts,followed by tibialis, QT, and BPTB grafts, with insufficient data to evaluate Tendo Achilles grafts. All have greater strength than the native ACL.Graft strength is only one of many factors contributing to knee stability after ACL reconstruction.grafts retain only about half their initial strength at long-term follow-up. Thus, grafts that are significantly stronger than the native ACL at time zero may indeed be necessary to produce ultimate strengths that are as strong as the ACL initially was.Allografts are increasing rapidly in populari

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • MRI confirmed anterior cruciate ligament tears in adults undergoing ACL reconstruction will be included in the study.

排除标准

  • Patients of knee injury where other graft options are used for ACL Recpnstruction.

结局指标

主要结局

We expect that the usable length and diameter of the quadrupled semitendinosus tendon will be more than 600mm and 8 mm after resection of flat terminal portion and muscle belly and keeping the cross-sectional diameter with circular or oval

时间窗: Baseline

次要结局

  • not appliocable(not applicable)

研究者

申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

Dr Nirmal Sanjaykumar Rathi

All India Institute of Medical Sciences,Raipur

研究点 (1)

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