Evaluation of the Effect of Subcutaneous Injection of Erythropoietin on Visual Functions in Patients With Late Onset Optic Neuropathy
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Assessment of visual acuity
研究概览
简要总结
This study aimed to investigate the therapeutic effect of subcutaneous erythropoietin in the management of late stage optic neuropathy.
详细描述
Injury of the optic nerve or optic neuropathy is one of the most common causes of vision loss. This study aimed to investigate the therapeutic effect of subcutaneous erythropoietin in the management of late stage optic neuropathy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with late stage optic neuropathy (1 month to 12 months after onset of optic neuropathy due to late referral of the cases)
排除标准
- •Patients with perforating ocular injuries were excluded.
研究组 & 干预措施
Systemic erythropoietin injections
20 patients diagnosed as late onset optic neuropathy that were attending Alexandria main university hospital.Systemic erythropoietin injections (eprax 10000 IU subcutaneous twice daily for three days).
干预措施: erythropoietin (Drug)
结局指标
主要结局
Assessment of visual acuity
时间窗: 3 months
Visual acuity using appropriate charts for assessment then convert into log of the minimum angle of resolution (logMAR) units to provide a numeric scale of visual acuity
Flash visual-evoked potentials
时间窗: 3 months
Flash VEP to detect amplitude reduction and latency in the optic nerve.
次要结局
未报告次要终点
研究者
Mohamed Fahmy Doheim
Prinicipal investigator
Alexandria University