The Hypersensitivity and Changes of Conditioned Pain Modulation in Chronic Neck Pain Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change of pressure pain threshold (PPT)
研究概览
简要总结
The aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific neck pain.
详细描述
Quantitative sensory testing is widely used in human research to investigate the state of the peripheral and central nervous system contributions in pain processing. It is a valuable tool to help identify central sensitization and may be important in the treatment of chronic neck pain. This study is a cross-sectional study. Two groups including chronic neck pain group and healthy volunteers group will be arranged in this study. The healthy subjects will be matched for sex and age in relation to the neck pain group. The pressure pain threshold (PPT) will be measured at the neck muscle in both groups. The cold pressor test will be used in both groups to activate conditioned pain modulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Age under 21 or over
- •Patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, nerve root compromise confirmed by clinical neurological tests or severe cardiorespiratory diseases.
- •Those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded.
- •Healthy volunteers
- •Inclusion criteria:
- •Age 21-80 years old.
- •These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
- •Exclusion Criteria:
- •Age below 21 or over 80 years old.
- •These participants have presented episodes of low back pain for more than 7 days in the last 12 months.
结局指标
主要结局
Change of pressure pain threshold (PPT)
时间窗: The PPT will be measured before CPT, 30 seconds after the CPT begin, and immediately after CPT.
A cold pressor test (CPT) was used to induce pain and trigger the conditioned pain modulation (CPM) response. The conditioned stimulus was immersion of the leg in a bucket of ice water on the side ipsilateral to the most painful neck region. The neck PPT was recorded beginning 30 s after immersion of the leg with two PPT measures for each point. The PPT will be also measured again immediately after CPT.
次要结局
- Numerical rating scale for pain (NRS)(The patients used this scale to rate the pain intensity of the neck pain before the experiment.)
研究者
guochen
Department of Spine Surgery
Peking University People's Hospital