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临床试验/NCT00768417
NCT00768417已完成不适用

Mastication of Almonds: Effects of Lipid Bioaccessibility, Appetite, and Hormone Response

Purdue University1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2006年4月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
20
试验地点
1
主要终点
Lipid available for absorption as measured by stool collections, appetite measures, blood analysis

研究概览

简要总结

Evidence indicates that almond consumption is associated with multiple health benefits. However, nuts are commonly excluded from diets on the basis that their high energy content may induce weight gain. Evidence from numerous studies show that this is not the case, yet the mechanism responsible for the less than predicted effect on weight is unknown. This study aimed to examine the effects of increased mastication on lipid bioavailability and satiety related peptide released in humans. Its purpose is to provide valuable mechanistic data to support the results from previous completed clinical studies.

详细描述

This cross-over study consisted of three study periods of four consecutive days separated by at least one week. During each day of the three study periods, participants were required to consume 55g of almonds split up into 5 g portions. They were required to chew the almonds 10, 25, or 40 times before swallowing, depending on the treatment. During each treatment period, all participants followed the same procedures over the four days. On day one after an overnight fast, participants reported to the laboratory and were presented with 11, 5 gram portions of almonds to chew 10, 25, or 40 times, depending on treatment arm. The participant remained in the laboratory for 4 hours post-almond consumption for measurements of blood and appetite. For the remainder of the 4 days, participants consumed all meals in the laboratory and collected all stools passed. On a separate occasion, recovered particle sizes of masticated almonds were measured by a mechanical sieving process. Individuals chewed almond samples either 10, 25 or 40 times and expectorated them into sieves.

研究设计

研究类型
Observational
观察模型
Case Crossover
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • 18-50 years of age
  • BMI 20-25 kg/m2
  • Full set of healthy teeth
  • Weight stable (<3 kg change in past 3 mo)

排除标准

  • Eating Disorders or high level of restraint
  • Endocrine disorders
  • Pregnant or lactating
  • Allergic to nuts
  • Taking medication likely to confound study outcomes (meds affecting appetite)

结局指标

主要结局

Lipid available for absorption as measured by stool collections, appetite measures, blood analysis

时间窗: 3, 4 day periods

次要结局

  • Particle size distribution as measured by mechanical sieving process(3 separate sessions)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Richard Mattes

Distinguished Professor, Foods and Nutrition

Purdue University

研究点 (1)

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