Tracking a Tactile Signal Along the Nervous System
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Conscious detection threshold
研究概览
简要总结
Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •right-hand dominance for participants who are neurotypical
- •age range of 18-23
- •participants who are neurotypical will be a similar age to the participants with stroke
- •participants who are neurotypical will have no musculoskeletal and neurological conditions
- •participants with stroke will have a single stroke incident resulting in a unilateral lesion (ischemic and hemorrhagic)
- •participants with stroke will be in the chronic phase (>1 year from stroke onset)
- •participants with stroke will have an onset of stroke after the age of 18
- •participants with stroke who meet the criteria of having the capacity to provide informed consent, regardless of aphasia
排除标准
- •pregnant women
- •prisoners
- •adults not capable of consenting on their own behalf.
- •participants with stroke who have used antispastic injections in the past six months
- •participants with stroke who have a lesion in the brainstem and/or cerebellum
- •participants with stroke who have a stroke arising due to brain surgery
- •participants with stroke who have hemineglect
研究组 & 干预措施
Stimulus magnitude
Differing levels of tactile stimulus will be applied
干预措施: Tactile stimulation (Behavioral)
结局指标
主要结局
Conscious detection threshold
时间窗: 30 minutes during the first session of a one session protocol
The magnitude at which a force stimulus applied to the finger can be first consciously detected. Different force levels will be applied, and the participant will indicate which of these forces can be detected. The changes in force applied will be in the units of N.
次要结局
- Brain activation(60 minutes during the first session of a one session protocol)
研究者
Netta Gurari
Assistant Professor
Virginia Polytechnic Institute and State University