Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 55
- 试验地点
- 2
- 主要终点
- Acute change in muscle size (cross sectional area, cm2)
研究概览
简要总结
There are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people.
The purpose of the present study is to assess the effects on muscle mass and function, tendon and bone of two different training intensities, light-moderate vs. heavy load, in people older than 65 years old.
The study will be carried out with a randomized controlled design. Participants will perform single training sessions and a 12-wk dynamic resistance training program on the knee extensors with different training intensities on each leg. One leg will train with heavy loads and the other one will train with light-moderate loads, but matching the load x repetitions performed by the contralateral side.
详细描述
The decline in muscle function provoked by the aging process and frailty are directly related to decreases in mobility and the ability to perform the so called "daily life activities". Resistance training is especially useful at this stage, given that it is an effective and widely applicable intervention to control and revert sarcopenia, and the deterioration of tendon and bone function. Despite of the effectiveness of heavy load resistance training, a controversy has arisen in the last years about the effects of lower load resistance training programs to achieve similar adaptations. This is because most of the studies that have compared light-moderate versus heavy load programs did not control the differences in total training load, measured as the overall mechanical work performed during the training program. Therefore, there are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people.
The purpose of the present study is to assess the effects on muscle mass and function, tendon and bone of two different training intensities, light-moderate vs. heavy load, in people older than 65 years old.
The studies will be carried out with a crossover (acute training sessions) and randomized controlled design (longitudinal training intervention). Participants will perform single training sessions with each resistance training intensity and a 12-wk dynamic resistance training program on the knee extensors with different training intensities on each leg. One leg will train with heavy loads and the other one will train with light-moderate loads, but matching the load x repetitions performed by the contralateral side. Muscle adaptations (EMG, muscle size and architecture), tendon mechanical properties, bone mineral density, blood parameters and life quality will be analyzed before and after the cessation of the training program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •65 years and older,
- •non-institutionalized
- •passed physical examination including physical function assessment (no frailty status; SPPB >7 points)
排除标准
- •Neurological, musculoskeletal, or other disorder that would preclude completing resistance training and all performance tests
- •Uncontrolled hypertension, unstable or exercise-induced angina pectoris or myocardial ischemia or any other medical condition that would interfere with testing or increase one's risk of complications during exercise.
- •History of regular resistance exercise during the previous 3 years
- •Knee prosthesis
结局指标
主要结局
Acute change in muscle size (cross sectional area, cm2)
时间窗: Change from baseline at 5 minutes after a training session
Ultrasound-based determination quadriceps muscle size and architecture.
Change in muscle size (cross sectional area, cm2)
时间窗: Change from baseline to week 12
Ultrasound-based determination quadriceps muscle size and architecture.
Acute change in muscle function (N)
时间窗: Change from baseline at 5 minutes after a training session
Force-velocity profile of the single-leg press exercise
Change in muscle function (N)
时间窗: Change from baseline to week 12
Force-velocity profile of the single-leg press exercise
次要结局
- Change in muscle excitation (mV)(Change from baseline to week 12)
- Change in patellar tendon stiffness (N/mm)(Change from baseline to week 12)
- Acute change in muscle excitation (mV)(Change from baseline at 5 minutes after a training session)
- Blood analysis: Change in oxidative stress(Change from baseline to week 12)
- Blood analysis: Acute change in Inflammation(Change from baseline at 5 minutes after a training session (Acute))
- Blood analysis: Acute change in anabolic processes(Change from baseline at 5 minutes after a training session)
- Change in bone mass (g)(Change from baseline to week 12)
- Blood analysis: Change in anabolic processes(Change from baseline to week 12)
- Blood analysis: Acute change in catabolic processes(Change from baseline at 5 minutes after a training session)
- Acute change in patellar tendon stiffness (N/mm)(Change from baseline at 5 minutes after a training session)
- Change in muscle mass (kg)(Change from baseline to week 12)
- Change in physical function(Change from baseline to week 12)
- Blood analysis: Change in inflammation(Change from baseline to week 12)
- Blood analysis: Acute change in oxidative stress(Change from baseline at 5 minutes after a training session)
- Blood analysis: Change in catabolic processes(Change from baseline to week 12)
研究者
Luis M. Alegre
Associate Professor
University of Castilla-La Mancha