Very Old Intensive Care Patients - Perfusion (VIPPER)
试验速览
- 阶段
- 不适用
- 状态
- 进行中(未招募)
- 发起方
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- bedside measurement of sublingual microcirculation
研究概览
简要总结
Shock is a frequent, etiologically heterogeneous and often lethal clinical condition of intensive care medicine. This is particularly true for very old intensive care patients (VIPs), who are among the fastest-growing subgroups of all intensive care unit (ICU) patients and who suffer from a significantly impaired outcome. In addition to the treatment of the causes of shock, current therapeutic approaches focus on the stabilization of vital parameters, which in general all reflect macrocirculatory measured values such as blood pressure. In contrast, a disturbance of the microcirculation (blood circulation of the smaller blood vessels <100 µm) is only poorly measurable and delayed. The last generation of AVA-Software (MicroVisionMedical) will calculate different parameters about the capillary densitiv and perfusion in a user-independent way. VIPPER investigates whether a non-invasive measurement of microcirculation using the sublingual mucosa in very old intensive care patients in shock leads to faster recognition and specific treatment of organ dysfunctions. Secondly, this study checks whether this measurement predicts outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 80 Years 至 —(Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 80 years
- •Acute ICU admission
- •Shock at the time point of admission to the ICU or in the first 3 hours defined as Lactate ≥ 2 mmol/l AND need for vasoactive substances to maintain a MAP ≥ 65 mmHg in the presence of adequate volume status
排除标准
- •< 80 years
- •Inaccessibility for sublingual measurement
- •no informed consent
结局指标
主要结局
bedside measurement of sublingual microcirculation
时间窗: after 24 hours
measurement of sublingual microcirculation by using MicroScan® microscope
次要结局
- Mortality(after 30 days, 6 months and 12 months)
- Use of Vasopressors and fluids(days from admission of the intensive care unit until discharge)
- Length of stay at ICU(tdays from admission of the intensive care unit until discharge)
