Pain Sensitivity in Acute Inflammatory Pain - Gender Differences and Validity of Sensory Tests
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- pain following burn injury
研究概览
简要总结
Pain is a complex experience influenced by gender and genetics, and, by psychosocial and sensory experiences. Pain sensitivity is thus highly variable between individuals.
In the present study we evaluate individuals´ pain perception in response to a number of different pain stimuli in 100 healthy volunteers (50 females and 50 males).
The data will allow us to assess pain sensitivity, to predict pain responses and to investigate gender related differences in pain perception.
A second aim is to evaluate the robustness of the different pain-tests since the tests are repeated with an interval of 2-4 weeks.
详细描述
Pain perception is affected by physiological, psychological, existential and demographic factors.
In the present study psychophysiological, psychological, genetic and demographic components in pain perception are evaluated in healthy volunteers (n = 100).
Psychophysical assessments following induction of a first degree burn injury (47.0 C, 420 s, 12.5 sq.cm, lower leg) include:
- pain during induction of burn injury
- thermal thresholds
- tactile thresholds
- electrical thresholds
- areas of secondary hyperalgesia
- pressure algometric assessments
- assessment of Diffuse Noxious Inhibitory Control (DNIC) efficiency
- assessment of (DNIC) using cold pressor test
Psychological assessments include:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •psychomotor ability to perform the tests
- •cognitive ability to perform the tests
排除标准
- •Body Mass Index > 28
- •participation in drug studies < 4 weeks prior to inclusion
- •chronic pain
- •chronic intake of analgesics
- •drug or alcohol abuse
- •intake of analgesics < 48 hours prior to study
- •females not on contraceptive therapy (intra-uterine device or p-pill)
- •lesion in the assessment area
结局指标
主要结局
pain following burn injury
时间窗: from baseline to 420 s after burn injury
次要结局
- pressure algometry assessments(95 min prior to burn injury)
- thermal thresholds(followed for 180 min after burn injury)
- DNIC-efficiency(45 min before burn injury)
- A118G SNP(8 months after inclusion completed)
- tactile thresholds(followed for 180 min after burn injury)
- cold pressor test(85 min before burn injury)
- HADS score(2 hours before the burn injury)
- PCS ratings(2 hours before the burn injury)
研究者
mads u werner
MD, DMSci
University of Copenhagen