ACTRN12608000448347已完成未知
Impact of Iron on Insulin Resistance and liver histology in non-alcoholic steatohepatitis.
Raines Medical Research Foundation0 个研究点目标入组 80 人开始时间: 2008年9月12日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- All
入选标准
- •Biopsy demonstrating NASH within six months of trial entry.
排除标准
- •Unable to provide informed consent
- •Ischemic heart disease
- •Pregnancy or lactation
- •Ferritin <50 ug/L
- •Venesection in the previous 12 months prior to trial entry
- •Other causes of liver disease: positive hepatitis B serology, positive hepatitis C serology, auto-antibodies, alpha-one anti-trypsin level and ceruloplasmin.
- •Acute or chronic inflammatory con ditions
- •Hereditary hemochromatosis (C282Y/C282Y or C282Y/H63D HFE gene mutation)
- •Alcohol consumption >20 grams/dat for males, >10 grams/day for females
- •Secondary causes of NAFLD (corticosteroids, gastro-intestinal bypass)
- •Use of anti-oxidants (vitamin E or C) or anti-TNF agents (pentoxifylline)
- •Poor glycaemic control diabetic (HbA1c>8.0%)
- •Decompensated cirrhosis INR(international normalized ratio)>1.3, albumin <35mg/dl or bilirubin >20 mmol/l or ascites or hepatic encephalopathy
- •Bleeding tendency precluding a repeat liver biopsy
- •Malignancy( excluding basal cell or squamous cell skin cancers)
研究者
相似试验
已完成
3 期
The effect of iron deficiency treatment on insulin resistanceCondition 1: Diabetes. Condition 2: Iron deficiency anemia.Diabetes mellitus due to underlying conditionIron deficiency anemiaIRCT20170215032587N3Ghoum University of Medical Sciences40
已完成
不适用
Effects of liver fibrosis on insulin resistance and beta-cell function in patients with type 2 diabetes: a cross-sectional studyType 2 diabetesJPRN-UMIN000026204Yokohama City University Graduate School of Medicine, Department of Gastroenterology and Hepatology100
已完成
3 期
Phlebotomy and Lifestyle and Diet Advices vs Lifestyle and Diet Advices Only in Patients With Dysmetabolic LiversiderosisIron OverloadLiver CirrhosisNCT01045525Rennes University Hospital274
进行中（未招募）
不适用
Glucose, Brain and MicrobiotaObesityNCT03889132Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta128
Enrolling By Invitation
不适用
Effect of Iron Chelation Therapy on Glucose Metabolism in Non-Transfusion-Dependent Thalassemicsthalassemia,Subject with non-transfusion dependent thalassemia with iron excess (serum ferritin >300 ng/mL)glucose metabolism,iron chelationTCTR20160523003o10