JPRN-UMIN000024198已完成未知
Frequency of T790M Mutation on Circulating Tumor DNA in EGFR-mutated NSCLC Patients With acquired resistance to irreversible EGFR-TKI :a prospective observational study - Frequency of T790M Mutation on ctDNA in patients with acquired resistance to irreversible EGFR-TKI
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 30
研究概览
简要总结
iquid biopsy detected EGFR mutations in 63.6% of the patients at diagnosis. Patients with positive EGFR mutations at diagnosis had significantly shorter overall and progression-free survival than patients with negative EGFR mutations. Four of 18 patients (22.2%) who reached progressive disease were positive EGFR T790M mutations. Only two patients were positive for major EGFR mutations at intermediate levels.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1 Patients with pre-treatment of EGFR-TKI 2 Exhibiting significant interstitial pneumonitis, or pulmonary fibrosis in the chest X-ray 3 Synchronous double or multiple cancer or metachronous double or multiple cancer 4 Uncontrolled pleural, ascites effusion or cardiac effusion 5 Patients with active co-morbidities including severe conditions. -Uncontrollable angina pectoris, myocardial infarction within 3 months, heart failure -Uncontrolled diabetes mellitus, hypertension -Severe infection -Patients whose participation in the trial is judged to be inappropriate by the attending doctor -Any other patients who are regarded as unsuitable for this trial by the attending doctor
研究者
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