NCT03477513已完成不适用
Personalized Treatment of Glioblastoma Via Image-Guided Predictive Modeling of Recurrence: A Single-Arm, Single Institutional Pilot Prospective Study of Dose-Escalated Radiation Therapy
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Adverse Events
研究概览
简要总结
The study is a pilot study to estimate the efficacy of personalized dose-escalation radiation therapy in patients with glioblastoma, as measured by estimating the median of progression-free survival. Toxicity, patterns of recurrence, and overall median survival will be measured as secondary endpoints. Adverse events will be monitored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with biopsy-proven WHO Grade IV glioblastoma, after gross-total or near-total resection, who are undergoing definitive chemoradiation as part of their treatment regimen
- •Age 18 or older
- •Ability to give signed informed consent
- •Karnofsky Performance Status (KPS) at least 70
排除标准
- •Placement of Gliadel wafers
- •Participation in another investigational trial
- •Active treatment of another malignancy
研究组 & 干预措施
Single Arm
Experimental
Dose-escalated radiation therapy
干预措施: Radation Therapy (Radiation)
结局指标
主要结局
Adverse Events
时间窗: 2 years
次要结局
未报告次要终点
研究者
研究点 (2)
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