JPRN-UMIN000003382已完成未知
Phase 1 trial of neoadjuvant chemotherapy with S1 plus radiation in patients with locally advanced rectal cancer - Phase 1 trial of neoadjuvant chemotherapy with S1 plus radiation in patients with locally advanced rectal cancer
Toho University School of Medicine0 个研究点目标入组 12 人开始时间: 2010年3月26日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 12
研究概览
简要总结
All patients achieved the planned 45 gray of radiation therapy There was no grade 3 toxicity The recommended dose of S-1 was determined to be 80 mg/day The dose intensity of S-1 was well maintained and the combination of S-1 plus radiation therapy was well tolerated by all patients Sphincter preserving procedures were possible in all but one (89%) patient High rates of tumor shrinkage and nodular downstaging were achieved The histological response rate was 78% including one complete response
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 80years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1.Impossible to receive TS-1 contained chemotherapy 2.Recieving the radiation therapy in a pelvis 3.Infection 4.Serious complications 5.Myocardial infarction within the last 6 months, previous serious medical illness or allergy for drug 6.Multiple malignancies 7. Pleural effusion or ascites requiring 8.Current or previous Brain metastasis 9.Diarrhea(watery stool) 10.Fresh bleeding of digestive organs 11.Need to treatment with flucytosine, atazanavir sulfate, or warfalin 12.Evidence of psychiatric disability interfering with enrollment to clinical trial 13.Pregnant or lactating women, women who are capable of pregnancy or intend to get pregnant 14.Man of wanting child 15.Need Systemically administration of corticosteroids 16.Patients judged inappropriate for this study by the physicians
研究者
相似试验
已完成
不适用
Pilot study of neoadjuvant chemotherapy with S-1 and oxaliplatin clinical Stage III gastric cancerGastric cancerJPRN-UMIN000031388Kyoto Katsura Hospital20
招募中
3 期
A phase III trial to confirm S-1 adjuvant chemotherapy for pathological stage II/III vulnerable elderly gastric cancer patients who underwent gastric resection (JCOG1507, BIRDIE)Gastric neoplasmJPRN-UMIN000025742Japan Clinical Oncology Group (JCOG)370
已完成
2 期
Phase2 trial of neoadjuvant chemotherapy with S-1 plus radiation in patients with locally advanced rectal cancerow rectal cancerJPRN-UMIN000013598Toho University School of Medicine30
已完成
不适用
Phase I/II trial of adjuvant chemotherapy of S-1 with CDDP for Stage III gastric cancerStage III gastric cancerJPRN-UMIN000004734School of Medicine, Keio University18
已完成
1 期
Phase I study of neo-adjuvant chemoradiation therapy for newly diagnosed malignant astrocytomasmalignant astyrocytomasJPRN-UMIN000015566Chiba Cancer Center20