Monoclonal Gammopathy of Undetermined Significance (MGUS) /Myeloma Awareness and Genetic Insights Campaign (MAGIC) Screening Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- Mayo Clinic
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Prevalence of monoclonal gammopathies across ancestrally diverse populations
研究概览
简要总结
This study is being done to screen adults for MGUS and to better understand the genetic and immune factors linked to this condition. Monoclonal gammopathy of undetermined significance or MGUS is a condition where an abnormal immune protein is found in the blood. MGUS is not cancer. In some people, it slowly develops into a blood cancer called multiple myeloma. MGUS occurs in people from all backgrounds. Researchers hope to use the information from this study to improve knowledge, early detection, and future care for everyone.
详细描述
PRIMARY OBJECTIVE:
I. To determine the prevalence of monoclonal gammopathies (MGUS, Smoldering and Multiple Myeloma) across ancestrally diverse populations in Minnesota, with prespecified, ancestry-informed analyses within East African, West African, Afro-Caribbean, and Non-Hispanic White groups.
OUTLINE: This is an observational study.
Participants undergo medical chart review and blood sample collection, as well as complete a questionnaire on study. Participants who test positive for MGUS are notified, along with their primary care physician, so that the necessary follow up and referral is provided as clinically indicated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults ≥ 40 years
- •Willing and able to review, understand, and provide consent before starting any study-specific procedures
- •Ability to complete questionnaire(s) by themselves or with assistance
排除标准
- •Pregnant women
研究组 & 干预措施
Observational
Participants undergo medical chart review and blood sample collection, as well as complete a questionnaire on study. Participants who test positive for MGUS are notified, along with their primary care physician, so that the necessary follow up and referral is provided as clinically indicated.
干预措施: Non-Interventional Study (Other)
结局指标
主要结局
Prevalence of monoclonal gammopathies across ancestrally diverse populations
时间窗: Up to 10 years
Screen for monoclonal gammopathies using mass spectrometry to detect monoclonal proteins among people across ancestrally diverse populations in Minnesota, with prespecified, ancestry-informed analyses within East African, West African, Afro-Caribbean, and Non-Hispanic White groups.
次要结局
未报告次要终点