Ultra-early Chest CT Improves Risk Prediction of Stroke-associated Pneumonia: Model Development and External Validation in a Multicentre Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,499
- 试验地点
- 5
- 主要终点
- Stroke-associated pneumonia
研究概览
简要总结
Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest CT findings remains uncertain. We developed and externally validated an early multimodal model combining clinical severity, inflammation, and chest CT abnormalities, and explored risk-stratified associations between prophylactic antibiotics and SAP.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients aged ≥18 years;
- •Admitted to a participating stroke centre with neuroimaging-confirmed acute ischaemic stroke ;
- •Had chest CT performed within 24 hours of stroke onset.
排除标准
- •Chest CT images unavailable or incomplete for assessment;
- •Insufficient clinical documentation to ascertain stroke-associated pneumonia occurrence within 7 days after stroke onset
研究组 & 干预措施
Development (Derivation) cohort
External validation cohort
结局指标
主要结局
Stroke-associated pneumonia
时间窗: within 7 days after stroke onset
SAP was defined as pneumonia occurring within 7 days after stroke onset. Potential events were screened using discharge diagnosis codes and medical record documentation, and then confirmed by manual chart review using prespecified clinical, laboratory, and radiological criteria consistent with the Pneumonia in Stroke Consensus Group and modified CDC definitions.
次要结局
未报告次要终点
研究者
Ji Xunming,MD,PhD
Professor of Neurology, Xuanwu Hospital, Capital Medical University
Capital Medical University