Influance of Walking Fatigability on Spatiotemporal Gait Parameters and Risk of Falling in Patients With Multiple Scalerosis

Multiple sclerosis (MS) is a chronic neurological disease that often affects mobility, balance, and endurance. Walking fatigability, defined as a decline in walking performance over time, is a common problem in individuals with MS and may increase the risk of falls. Understanding how walking fatigability influences gait patterns and fall risk is essential for designing targeted rehabilitation strategies.

This observational study aims to investigate the relationship between walking fatigability, spatiotemporal gait parameters, and fall risk in individuals with MS. Participants will be recruited from Alexandria University Hospital and will be divided into two groups based on the presence or absence of walking fatigability. Inclusion criteria include confirmed MS diagnosis, ability to walk independently, and willingness to provide informed consent. Exclusion criteria include acute MS relapse, comorbid conditions affecting gait, or cognitive impairment that prevents safe participation.

Participants will undergo 6-Minute Walk Test to assess walking performance, and gait parameters such as step length and double time support.and gait speed will be recorded. Fall risk will be evaluated using a Timed Up and Go (TUG) test and The Falls Efficacy Scale-International (FES-I).

Data will be analyzed to compare gait changes and fall risk between the two groups. Correlations between walking fatigability and specific gait parameters will be explored to identify patterns associated with higher fall risk. The findings of this study are expected to inform clinical decision-making and rehabilitation approaches, contributing to safer and more effective mobility management for individuals with MS.