Randomised Prospective Comparative Clinical Study Of Dexmedetomidine Vs Clonidine For Hemodynamic Stability During Laproscopic Surgeries In General Anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- 1. To evaluate and compare the intraoperative hemodynamic parameter with intravenous dexmedetomidine and intravenous clonidine as premedication during laproscopic surgeries under general anaesthesia.
研究概览
简要总结
This study is randomized ,controlled,parallel group,single centre trial comparing the hemodynamic stability of dexmedetomidine and clonidine during laproscopic surgery in general anesthesia.The study will be conducted over 18 months in 120 patients in subharati medical college,Meerut,UP ,India.The Primary Outcome measures will be to evaluate and compare the intraoperative hemodynamic parameter with intravenous dexmedetomidine and cloniodine as premedication during laproscopic surgeries in general anaesthesia.The secondary outcomes will be to evaluate side effects of intravenous dexmedetomidine and clonidine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Physical status I and II.
排除标准
- •Patient refusal
- •History of laryngeal or tracheal surgery or pathology.
- •History of Bronchial asthma,
- •History of smoking, alcohol addiction or drug abuse.
- •Patients with coexisting systemic illness, morbid obese patient, neurological or psychological disease, hepatic or renal dysfunction, endocrinal or metabolic disorder.
- •Patients with hypertensive heart disease or on antihypertensives, beta blockers or calcium channel blockers.
- •Age less than 18 or more than
- •Basal heart rate less than 60 and patient with heart block or with conduction defect.
- •Active upper respiratory tract infections.
- •Pregnant or lactating female.
结局指标
主要结局
1. To evaluate and compare the intraoperative hemodynamic parameter with intravenous dexmedetomidine and intravenous clonidine as premedication during laproscopic surgeries under general anaesthesia.
时间窗: vital monitoring was done at baseline ,1 min before premedication ,1 min after premedication,1 min before induction,1 min after induction,1 min before intubation ,1 min after intubation,2 min,4 min,6 min,8 min ,10 min ,1 min after CO2 insufflation,after 15 min,at 5 min time interval up to 90 min .
次要结局
- To evaluate Side effects of intravenous dexmedetomidine and clonidine.(1 min after giving drugs,2min,4min,6min,8min 10 min at 5 min time interval up to 90 min .)