Cardiopulmonary Health Effects of Indoor Air Purification and Other Indoor Environmental Conditions Among Young Healthy Adults in Beijing, China
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 81
- 试验地点
- 2
- 主要终点
- Changes in blood pressure
研究概览
简要总结
This study aims to explore the cardiopulmonary health effects of indoor air purification and other indoor environmental conditions among young healthy college students in Beijing, China.
详细描述
The present randomized, double-blind crossover study was conducted to investigate the cardiopulmonary health effects of air purification among 81 young healthy college students in Beijing, China. Real or sham purification was performed in the dormitories for 4 days, following a 15-day wash-out period in the intervals. During the study periods, the investigators collected indoor exposure levels of size-fractionated particulate matter (PM), black carbon (BC), noise, ozone, nitrogen dioxide, carbon dioxide, volatile organic compounds, temperature, relative humidity, illumination, and microorganism. Biological specimens (i.e., morning urine, fasting venous blood, exhaled breath condensate, and nasal mucus) were also collected and examined. Some important individual factors including demographical information (age, sex, height, weight, etc.), physical activity, sleep condition, mood and cognition, and food intake were also gathered using questionaire or anthropometric measurements, in order to control for the potential confounding effects. For further data analyses, air pollutants, noise, and other exposures would be controlled as confounders when addressing the health effects associated with air purification, and would also be used to explore their effects on cardiopulmonary health. The interaction effects of air pollutants, noise, and other exposures on cardiopulmonary health would also be explored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 28 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Living in Beijing for more than one consecutive years;
- •College students between 18-28 years;
排除标准
- •Current or past smokers;
- •Body mass index (BMI) over 28.0 kg/m
- •Alcohol addict;
- •Having thoracic surgery history;
- •History of diagnosed chronic disease;
- •Hepatitis B / hepatitis C virus patient / carrier;
- •Unwilling or unable to provide informed consent or cooperate with all research related procedures.
结局指标
主要结局
Changes in blood pressure
时间窗: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
Including the systolic blood pressure (SBP) in mmHg, diastolic blood pressure (DBP) in mmHg, and pulse pressure (PP) in mmHg.
Changes in pulmonary function
时间窗: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
Including forced expiratory volume in 1 s (FEV1) in liter, forced vital capacity (FVC) in liter, forced expiratory volume in 1 s (FEV1) / forced vital capacity (FVC) ratio, and peak expiratory flow (PEF) in liter per second.
Changes in heart rate variability
时间窗: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
Including the standard deviation of all normal-to-normal R-R intervals (SDNN) in millisecond, standard deviation of sequential five-minute R-R interval means (SDANN) in millisecond, root-mean-square difference of successive normal R-R intervals (rMSSD) in millisecond, low frequency (LF) in squared millisecond, and high frequency (HF) in squared millisecond.
次要结局
- Changes in levels of cognitive function(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of 8-hydroxydeoxyguanosine (8-OHdG)(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of glucose metabolites in serum(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of airway inflammation(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of sleep-breathing parameters(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of cognitive function-related biomarkers(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of blood cell parameters(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of microbiomics in nasal mucus(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of sleep-related parameters(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of C-reactive protein (CRP)(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of systematic inflammation and oxidative stress indicators(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of neurotransmitter metabolites in serum(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of microbiomics in EBC(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
- Changes in levels of pituitary-related hormones(Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention))
研究者
Furong Deng
MD & PhD, Professor, Deputy Director Department of Occupational & Environmental Health Sciences
Peking University