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临床试验/NCT02327208
NCT02327208已完成不适用

Effects of Carbohydrate and Protein Supplementation on Whole-body Protein Balance and Skeletal Muscle Mass During Winter Military Training: a Randomized Controlled Trial

United States Army Research Institute of Environmental Medicine4 个研究点 分布在 2 个国家目标入组 73 人开始时间: 2015年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
73
试验地点
4
主要终点
Body weight

研究概览

简要总结

The objectives of this study are to: 1) determine effects of a prototype recovery food product providing supplemental energy on whole-body protein balance, skeletal muscle mass, and biomarkers of physiological status and strain during winter military training, and 2) determine the extent to which varying macronutrient composition (protein-based [PRO] versus carbohydrate-based [CHO]) of the food product modulates the physiological consequences to strenuous military training.

详细描述

Up to 120 Norwegian Soldiers from the 2nd Battalion, Brigade North, Norwegian Army stationed at Skjold Garrison will be enrolled in a 9-day, randomized controlled study. Using dietary analysis, body composition assessments, stable isotope methodologies, basic biochemical techniques, and measures of physiological strain, the effects of supplemental energy in the form of carbohydrate and protein on indices of muscle mass and physiological status will be assessed.

We hypothesize that consuming supplemental energy will attenuate the effects of severe energy deficit on inflammation, androgenic hormones, and whole-body protein retention, thereby protecting skeletal muscle mass. We expect that consuming PRO will promote a more favorable recovery than consuming CHO, as indicated by measures of increased whole-body protein synthesis and greater conservation of skeletal muscle mass.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Male and female Norwegian Soldiers aged 18 years or older participating in the 4-day training program.

排除标准

  • History of skin irritation (e.g., nickel or adhesive allergy), difficulty swallowing large pills, and allergies to dairy products

结局指标

主要结局

Body weight

时间窗: day 5

Lean Body Mass

时间窗: day 5

Body composition

Skeletal Muscle Mass

时间窗: day 5

Isotopic estimates of muscle protein mass

Protein Balance

时间窗: day 5

Whole-body nitrogen balance

次要结局

  • Intestinal health(day 5)
  • Thermal and Physiological Strain(average 6 days)

研究者

发起方
United States Army Research Institute of Environmental Medicine
申办方类型
Fed
责任方
Principal Investigator
主要研究者

Stefan Pasiakos

Nutritional Physiologist

United States Army Research Institute of Environmental Medicine

研究点 (4)

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